Review: Radioactive Microspheres for Medical Applications
نویسنده
چکیده
This paper reviews the preparation and application of radioactive microspheres for medical purposes. It first discusses the properties of relevant radioisotopes and then explores the diagnostic uses of gammaemitter labeled microspheres, such as blood flow measurement and imaging of the liver and other organs. The therapeutic uses of alphaand beta-emitting microspheres, such as radioembolization, local tumor therapy and radiosynovectomy, are then described, and the recent developments in neutron capture therapy using gadolinium microspheres and boron liposomes discussed. The review concludes with some considerations in radiopharmaceutical kit preparations and radioisotope generator use, as well as with some radiobiological and dosimetric concerns.
منابع مشابه
Progress in research and application of PLGA embolic microspheres.
Transcatheter arterial chemoembolization was an important method in the treatment of solid cancers and the effectiveness of such treatment depends on the nature of embolic agent. Due to the biocompatibility, controllable degradation rate, and both hydrophobicity-hydrophilicity, researches of application on poly(lactic-co-glycolic acid) (PLGA) in medical practice has been ongoing for more than 4...
متن کاملProduction of yttrium aluminum silicate microspheres by gelation of an aqueous solution containing yttrium and aluminum ions in silicone oil
Background: Radioactive yttrium glass microspheres are used for liver cancer treatment. These yttrium aluminum silicate microspheres are synthesized from yttrium, aluminum and silicone oxides by melting. There are two known processes used to transform irregular shaped glass particles into microspheres, these ‘spheroidization by flame’ and ‘spheroidization by gravitational fall...
متن کاملPreparation, Characterization and Evaluation of Drug Release Properties of Simvastatin-loaded PLGA Microspheres
Microspheres formulated from poly (D,L-lactic-co-glycolide) (PLGA), a biodegradable polymer, have been extensively evaluated as a drug delivery system. In this study, the preparation, characterization and drug release properties of the PLGA microspheres were evaluated. Simvastatin (SIM)-loaded PLGA microspheres were prepared by oil-in-water emulsion/solvent evaporation method. The microspheres ...
متن کاملPolymeric Microspheres for Medical Applications
Synthetic polymeric microspheres find application in a wide range of medical applications. Among other applications, microspheres are being used as bulking agents, embolicor drug-delivery particles. The exact composition of the spheres varies with the application and therefore a large array of materials has been used to produce microspheres. In this review, the relation between microsphere synt...
متن کاملMicrospheres: a Brief Review
Microspheres are multiparticulate drug delivery systems which are prepared to obtain prolonged or controlled drug delivery to improve bioavailability, stability and to target the drug to specific site at a predetermined rate. They are made from polymeric waxy or other protective materials such as natural, semi synthetic and synthetic polymers. Microspheres are characteristically free flowing po...
متن کامل